Market Players Focus on Developing Sophisticated Pharmaceuticals for Treatment-Resistant Depression


Global treatment-resistant depression market expected to reach $4.0 billion by 2033 with innovative nasal and intravenous drugs offering quicker and more effective results.

The global Treatment-Resistant Depression TreatmentMarket Size is expected to be worth US$ 1.69 billion in 2023. Because of the increasing prevalence of depression and anxiety disorders in adults, as well as the ageing population, global demand for treatment-resistant depression treatment is predicted to grow at a CAGR of 9.0% between 2023 and 2033, reaching approximately US$ 4.0 billion by 2033. The rising prevalence of Treatment-Resistant Depression has increased public awareness of its therapeutic options. Several market players are developing sophisticated drugs that can be administered via nasal and intravenous channels rather than the traditional oral route.

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Traditional antidepressants used for this disease may take at least 4-6 weeks to work, with the risk of only producing partial or poor results when taken orally, whereas intranasal has been demonstrated to offer greater results within hours of administration. In a January 2022 study published in Pharmacopsychiatry, for example, Novartis Pharmaceuticals' novel pipeline antidepressant MIJ821 showed a more significant reduction in depressive episodes within 24 hours of dosing by infusion weekly among patients. 

Furthermore, the total results demonstrated that intranasal esketamine combined with a novel oral antidepressant was more effective than placebo plus oral administration. Intranasal esketamine reduced depressive symptoms quickly and delayed relapse time. Furthermore, greater R&D for sophisticated pharmaceuticals via new means of administration is predicted to improve drug demand, hence expanding total market growth.

The World Health Organisation (WHO) reports that the prevalence of mental health disorders and afflictions is rising worldwide. There has been a 13% increase in mental health disorders and other depressive conditions in the last decade. According to the US Department of Health and Human Services (HHS), 17.0% (about 4.1 million people) of adolescents aged 12 to 17 experienced a major depressive episode (MDE) in 2020, with 12% (about 2.9 million people) experiencing an MDE with severe impairment.

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Key Takeaways from the Market Study

  • By the end of 2022, the global treatment-resistant depression therapy market was valued at US$ 1.55 billion.
  • From 2018 to 2022, market demand increased at a 3.3% CAGR.
  • The NMDA sector of the market accounts for the majority of the market with a 49% market share.
  • With a 47% market share, the Hospital Pharmacies category dominates the market by Distribution Channel.
  • Treatment-Resistant Depression Treatment revenues are predicted to grow at a 9.0% CAGR from 2023 to 2033.
  • The market for Treatment-Resistant Depression Treatment is anticipated to reach US$ 4.0 billion by 2033.

“The rising geriatric population is one of the factors that is anticipated to boost the growth of treatment-resistance depression treatment market, as the treatment-resistance depression treatment is high in this age group population,” remarks an FMI analyst.

Competitive Landscape

Prominent players in the treatment-resistant depression treatment market are Janssen Global Services, LLC, AbbVie Inc., Sandoz International GmbH (Novartis AG), H. Lundbeck A/S, Par Pharmaceutical (Endo International plc), Otsuka Pharmaceutical Co., Ltd., and AstraZeneca, among others. 

Recent Developments:

  • In August 2022, Merck Sharp & Dohme LLC initiated Phase IIa clinical trial to evaluate the safety and efficacy of MK-1942 among treatment-resistant depression patients.
  • In July 2022,Novartis Pharmaceuticals announced that it would initiate a Phase 2 clinical trial of MIJ821 (ketamine) for treatment-resistant depressive disorders in September 2022.
  • In May 2022, COMPASS Pathways presented positive data for Phase IIb study of COMP360 psilocybin therapy for treatment-resistant depression treatment at the American Psychiatric Association annual meeting in New Orleans.
  • In February 2022, Denova Biopharma secured US FDA approval to initiate a Phase 2b clinical trial to analyze the efficacy and safety of DB104 (liafensine) in patients with treatment-resistant mood disorder.

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Key Segments Covered in the Treatment-Resistant Depression Treatment Industry Analysis

Treatment-Resistant Depression Treatment Market by Drug Type:

  • NMDA
  • Antidepressants
  • Antipsychotics
  • Others

Treatment-Resistant Depression Treatment Market by Distribution Channel:

  • Hospital Pharmacies
  • Drug Stores & Retail Pharmacies
  • Online Pharmacies

Treatment-Resistant Depression Treatment Market by Region:

  • North America
  • Latin America
  • Europe
  • South Asia & Pacific
  • East Asia
  • Middle East & Africa

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Published in

Health

Published on

Jul 14, 2023

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